Welcome to Presaging Critical Residues in Protein interface - Database (PCRPi-Db). PCRPi-Db is a searchable database of hot spot prediction in protein interfaces. PCRPi is a novel method to predict critical residues in protein interfaces. The method relies in the integration of seven different types of sources of information by using Bayesian networks (BNs). Each individual measure provides a different type of information, i.e. Energetic (BE) , structure-based (IE & TOP) and sequence-based features (CON, ANCON, 3DCON & ANC3DCON). Naive and expert BNs were trained to distinguish between critical and non-critical residues taken from a benchmark dataset of 25 protein complexes.